Basic Pharmacology of Losartan . Review Article

Abstract

Renin angiotensin system has been for a long time a focus of researchers from all over the scientific community and in particular physiology and pharmacology. Angiotensin-II is a potent vasoconstrictor; it raises the total peripheral resistance and hence; blood pressure. Angiotensin-II also affects the remodeling of the heart. Losartan was developed to block the receptor of Angiotensin-II, lowering the elevated blood pressure and a positively affect the hemodynamics of the heart.